Neonates are highly susceptible to seizures, often leading to short or long-term neurological impairments. However, clinical manifestations of neonatal seizures are subtle and often lead to misdiagnoses. This increases the risk of prolonged, untreated seizure activity and subsequent brain injury. Continuous video electroencephalogram (cEEG) monitoring is the gold standard for seizure detection. However, this is an expensive evaluation that requires expertise and time. In this study, we propose a convolutional neural network-based model for early prediction of neonatal seizures by distinguishing between interictal and preictal states of the EEG. Our model is patient-independent, enabling generalization across multiple subjects, and utilizes mel-frequency cepstral coefficient matrices extracted from multichannel EEG and electrocardiogram (ECG) signals as input features. Trained and validated on the Helsinki neonatal EEG dataset with 10-fold cross-validation, the proposed model achieved an average accuracy of 97.52%, sensitivity of 98.31%, specificity of 96.39%, and F1-score of 97.95%, enabling accurate seizure prediction up to 30 minutes before onset. The inclusion of ECG alongside EEG improved the F1-score by 1.42%, while the incorporation of an attention mechanism yielded an additional 0.5% improvement. To enhance transparency, we incorporated SHapley Additive exPlanations (SHAP) as an explainable artificial intelligence method to interpret the model and provided localization of seizure focus using scalp plots. The overall results demonstrate the model's potential for minimally supervised deployment in neonatal intensive care units, enabling timely and reliable prediction of neonatal seizures, while demonstrating strong generalization capability across unseen subjects through transfer learning.

In this study, we present a deep learning framework that learns complex spatio-temporal correlation structures of EEG signals through a Spatio-Temporal Attention Network (ST AN) for accurate predictions of onset of seizures for Epilepsy patients. Unlike existing methods, which rely on feature engineering and/or assume fixed preictal durations, our approach simultaneously models spatio-temporal correlations through ST AN and employs an adversarial discriminator to distinguish preictal from interictal attention patterns, enabling patient-specific learning. Evaluation on CHB-MIT and MSSM datasets demonstrates 96.6% sensitivity with 0.011/h false detection rate on CHB-MIT, and 94.2% sensitivity with 0.063/h FDR on MSSM, significantly outperforming state-of-the-art methods.

Forecasting epileptic seizures from multivariate EEG signals represents a critical challenge in healthcare time series prediction, requiring high sensitivity, low false alarm rates, and subject-specific adaptability. We present STAN, an Adversarial Spatio-Temporal Attention Network that jointly models spatial brain connectivity and temporal neural dynamics through cascaded attention blocks with alternating spatial and temporal modules. Unlike existing approaches that assume fixed preictal durations or separately process spatial and temporal features, STAN captures bidirectional dependencies between spatial and temporal patterns through a unified cascaded architecture. Adversarial training with gradient penalty enables robust discrimination between interictal and preictal states learned from clearly defined 15-minute preictal windows. Continuous 90-minute pre-seizure monitoring reveals that the learned spatio-temporal attention patterns enable early detection: reliable alarms trigger at subject-specific times (typically 15-45 minutes before onset), reflecting the model's capacity to capture subtle preictal dynamics without requiring individualized training. Experiments on two benchmark EEG datasets (CHB-MIT scalp: 8 subjects, 46 events; MSSM intracranial: 4 subjects, 14 events) demonstrate state-of-the-art performance: 96.6% sensitivity with 0.011 false detections per hour and 94.2% sensitivity with 0.063 false detections per hour, respectively, while maintaining computational efficiency (2.3M parameters, 45 ms latency, 180 MB memory) for real-time edge deployment. Beyond epilepsy, the proposed framework provides a general paradigm for spatio-temporal forecasting in healthcare and other time series domains where individual heterogeneity and interpretability are crucial.

In recent years, machine learning has become an increasingly powerful tool for supporting seizure detection and monitoring in epilepsy care. Traditional approaches focus on identifying seizures only after they begin, which limits the opportunity for early intervention and proactive treatment. In this study, we propose a novel approach that integrates both real-time seizure detection and prediction, aiming to capture subtle temporal patterns in EEG data that may indicate an upcoming seizure. Our approach was evaluated using the CHB-MIT Scalp EEG Database, which includes 969 hours of recordings and 173 seizures collected from 23 pediatric and young adult patients with drug-resistant epilepsy. To support seizure detection, we implemented a range of supervised machine learning algorithms, including K-Nearest Neighbors, Logistic Regression, Random Forest, and Support Vector Machine. The Logistic Regression achieved 90.9% detection accuracy with 89.6% recall, demonstrating balanced performance suitable for clinical screening. Random Forest and Support Vector Machine models achieved higher accuracy (94.0%) but with 0% recall, failing to detect any seizures, illustrating that accuracy alone is insufficient for evaluating medical ML models with class imbalance. For seizure prediction, we employed Long Short-Term Memory (LSTM) networks, which use deep learning to model temporal dependencies in EEG data. The LSTM model achieved 89.26% prediction accuracy. These results highlight the potential of developing accessible, real-time monitoring tools that not only detect seizures as traditionally done, but also predict them before they occur. This ability to predict seizures marks a significant shift from reactive seizure management to a more proactive approach, allowing patients to anticipate seizures and take precautionary measures to reduce the risk of injury or other complications.

The training of deep learning models in seizure prediction requires large amounts of Electroencephalogram (EEG) data. However, acquiring sufficient labeled EEG data is difficult due to annotation costs and privacy constraints. Federated Learning (FL) enables privacy-preserving collaborative training by sharing model updates instead of raw data. However, due to the inherent inter-patient variability in real-world scenarios, existing FL-based seizure prediction methods struggle to achieve robust performance under heterogeneous client settings. To address this challenge, we propose FedL2T, a personalized federated learning framework that leverages a novel two-teacher knowledge distillation strategy to generate superior personalized models for each client. Specifically, each client simultaneously learns from a globally aggregated model and a dynamically assigned peer model, promoting more direct and enriched knowledge exchange. To ensure reliable knowledge transfer, FedL2T employs an adaptive multi-level distillation strategy that aligns both prediction outputs and intermediate feature representations based on task confidence. In addition, a proximal regularization term is introduced to constrain personalized model updates, thereby enhancing training stability. Extensive experiments on two EEG datasets demonstrate that FedL2T consistently outperforms state-of-the-art FL methods, particularly under low-label conditions. Moreover, FedL2T exhibits rapid and stable convergence toward optimal performance, thereby reducing the number of communication rounds and associated overhead. These results underscore the potential of FedL2T as a reliable and personalized solution for seizure prediction in privacy-sensitive healthcare scenarios.

--Developing accurate and generalizable epileptic seizure prediction models from electroencephalography (EEG) data across multiple clinical sites is hindered by patient privacy regulations and significant data heterogeneity (non-IID characteristics). Federated Learning (FL) offers a privacy-preserving framework for collaborative training, but standard aggregation methods like Federated A veraging (FedA vg) can be biased by dominant datasets in heterogeneous settings. This paper investigates FL for seizure prediction using a single EEG channel across four diverse public datasets (Siena, CHB-MIT, Helsinki, NCH), representing distinct patient populations (adult, pediatric, neonate) and recording conditions. We implement privacy-preserving global normalization and propose a Random Subset Aggregation strategy, where each client trains on a fixed-size random subset of its data per round, ensuring equal contribution during aggregation. Our results show that locally trained models fail to generalize across sites, and standard weighted FedA vg yields highly skewed performance (e.g., 89.0% accuracy on CHB-MIT but only 50.8% on Helsinki and 50.6% on NCH). In contrast, Random Subset Aggregation significantly improves performance on under-represented clients (accuracy increases to 81.7% on Helsinki and 68.7% on NCH) and achieves a superior macro-average accuracy of 77.1% and pooled accuracy of 80.0% across all sites, demonstrating a more robust and fair global model. This work highlights the potential of balanced FL approaches for building effective and generalizable seizure prediction systems in realistic, heterogeneous multi-hospital environments while respecting data privacy. Epilepsy is a prevalent neurological disorder characterized by recurrent, unpredictable seizures, significantly impacting the quality of life and safety of millions worldwide [1].

Epilepsy is a chronic, noncommunicable brain disorder, and sudden seizure onsets can significantly impact patients' quality of life and health. However, wearable seizure-predicting devices are still limited, partly due to the bulky size of EEG-collecting devices. To relieve the problem, we proposed a novel two-stage channel-aware Set Transformer Network that could perform seizure prediction with fewer EEG channel sensors. We also tested a seizure-independent division method which could prevent the adjacency of training and test data. Experiments were performed on the CHB-MIT dataset which includes 22 patients with 88 merged seizures. The mean sensitivity before channel selection was 76.4% with a false predicting rate (FPR) of 0.09/hour. After channel selection, dominant channels emerged in 20 out of 22 patients; the average number of channels was reduced to 2.8 from 18; and the mean sensitivity rose to 80.1% with an FPR of 0.11/hour. Furthermore, experimental results on the seizure-independent division supported our assertion that a more rigorous seizure-independent division should be used for patients with abundant EEG recordings.

Early management and better clinical outcomes for epileptic patients depend on seizure prediction. The accuracy and false alarm rates of existing systems are often compromised by their dependence on static thresholds and basic Electroencephalogram (EEG) properties. A novel Recurrent Neural Network (RNN)-based method for seizure start prediction is proposed in the article to overcome these limitations. As opposed to conventional techniques, the proposed system makes use of Long Short-Term Memory (LSTM) networks to extract temporal correlations from unprocessed EEG data. It enables the system to adapt dynamically to the unique EEG patterns of each patient, improving prediction accuracy. The methodology of the system comprises thorough data collecting, preprocessing, and LSTM-based feature extraction. Annotated EEG datasets are then used for model training and validation. Results show a considerable reduction in false alarm rates (average of 6.8%) and an improvement in prediction accuracy (90.2% sensitivity, 88.9% specificity, and AUC-ROC of 93). Additionally, computational efficiency is significantly higher than that of existing systems (12 ms processing time, 45 MB memory consumption). About improving seizure prediction reliability, these results demonstrate the effectiveness of the proposed RNN-based strategy, opening up possibilities for its practical application to improve epilepsy treatment.

This paper introduces an innovative framework designed for progressive (granular in time to onset) prediction of seizures through the utilization of a Deep Learning (DL) methodology based on non-invasive multi-modal sensor networks. Epilepsy, a debilitating neurological condition, affects an estimated 65 million individuals globally, with a substantial proportion facing drug-resistant epilepsy despite pharmacological interventions. To address this challenge, we advocate for predictive systems that provide timely alerts to individuals at risk, enabling them to take precautionary actions. Our framework employs advanced DL techniques and uses personalized data from a network of non-invasive electroencephalogram (EEG) and electrocardiogram (ECG) sensors, thereby enhancing prediction accuracy. The algorithms are optimized for real-time processing on edge devices, mitigating privacy concerns and minimizing data transmission overhead inherent in cloud-based solutions, ultimately preserving battery energy. Additionally, our system predicts the countdown time to seizures (with 15-minute intervals up to an hour prior to the onset), offering critical lead time for preventive actions. Our multi-modal model achieves 95% sensitivity, 98% specificity, and 97% accuracy, averaged among 29 patients.

Epileptic seizures cause abnormal brain activity, and their unpredictability can lead to accidents, underscoring the need for long-term seizure prediction. Although seizures can be predicted by analyzing electroencephalogram (EEG) signals, existing methods often require too many electrode channels or larger models, limiting mobile usability. This paper introduces a SlimSeiz framework that utilizes adaptive channel selection with a lightweight neural network model. SlimSeiz operates in two states: the first stage selects the optimal channel set for seizure prediction using machine learning algorithms, and the second stage employs a lightweight neural network based on convolution and Mamba for prediction. On the Children's Hospital Boston-MIT (CHB-MIT) EEG dataset, SlimSeiz can reduce channels from 22 to 8 while achieving a satisfactory result of 94.8% accuracy, 95.5% sensitivity, and 94.0% specificity with only 21.2K model parameters, matching or outperforming larger models' performance. We also validate SlimSeiz on a new EEG dataset, SRH-LEI, collected from Shanghai Renji Hospital, demonstrating its effectiveness across different patients. The code and SRH-LEI dataset are available at https://github.com/guoruilu/SlimSeiz.